Identification of regulatory genes and potential drug targets:  Xactagen services include screening our reporter assays with siRNA libraries.  These libraries include functionally defined siRNA libraries (e.g., covering all kinases, phosphatases, GPCRs, etc.) or siRNA directed against the “druggable” human genome.  Screening reporter cells for genes identified by genomics identifies regulatory genes and pathways for those genes, while screening reporter assays for genes associated with human disease identifies drug candidates.

Discovery of interactive genes in pursuit of Personalized Medicine:  Xactagen services include screening disease-relevant reporter gene assays with siRNA libraries to associate biomarkers with enhancement or suppression of drug candidate delivery and activity.  The data is then used to assist in identifying biomarkers to define those patients most likely to benefit and those patients least likely to benefit from the drug.

Assessing siRNA delivery and activity – In Vitro:  Xactagen services include production of gene-specific reporter assays followed by screening of gene-specific siRNAs to demonstrate siRNA delivery and activity.

SCREENING SERVICES AVAILABLE