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REPORTER CELL LIBRARIES

Xactagen provides gene expression reporter cells delivered to your laboratory. Proprietary Xactagen reporter cells can be used for both in vitro and for in vivo studies.  Contact us at info@xactagen.com for pricing and delivery.

Custom Developed Reporter Cells are also available.  Contact us, click Custom Reporter Cell Libraries, or Custom-Produced Reporter Cells to learn more.

We are developing a large library of reporter cells that are now becoming available.  Reporter cells are being produced in Breast, Colon, Prostate, Lung, and Ovarian cancer cell lines  We will expand into more tumor cells and to non-tumor cells in 2009.  Reporters are introduced into endogenous genes to provide accurate readouts of gene regulation due to native promoters, enhancer elements, suppressor elements, and chromosomal modifications that can span tens to hundreds of kilobases.  Reporter mRNAs contain natural 5' and 3' untranslated regions (UTRs) to provide accurate readouts of mRNA stability (e.g., regulation by mRNAs).  Vectors have been optimized to provide an excellent signal-to-noise ratio, as required for High Throughput Screening (HTS).  Xactagen reporter gene assays are amenable to bench-top research or to HTS.


Catalogs of Available
Reporter Cells

HCT116
Colon Cancer
Genes

A549
Lung Cancer
Genes


HCT116 Colon Cancer Library

Known and Hypothetical Genes

       

CELL LINE

INDICATION

LOCUS

GENE NAME

GENE PRODUCT

ACCESSION NO.

HCT116

Colon Cancer

6q25.1

AKAP12

A-kinase anchor protein 12 isoform 1

NM_005100

HCT116

Colon Cancer

18p11.21

C18orf19

hypothetical protein LOC125228

NM_152352

HCT116

Colon Cancer

2q31.3

CERKL

ceramide kinase-like isoform a

NM_001030311

HCT116

Colon Cancer

15q26.1

CHD2

chromodomain helicase DNA binding protein 2

NM_001271

HCT116

Colon Cancer

4p12

COX7B2

cytochrome c oxidase subunit VIIb2

NM_130902

HCT116

Colon Cancer

Xp22.33

CSF2RA

colony stimulating factor 2 receptor alpha chain

NM_006140

HCT116

Colon Cancer

Yp11.32

CSF2RA

colony stimulating factor 2 receptor alpha chain

NM_006140

HCT116

Colon Cancer

3q12.1

DCBLD2

discoidin, CUB and LCCL domain containing 2

NM_080927

HCT116

Colon Cancer

18q22.2

DOK6

docking protein 5-like

NM_152721

HCT116

Colon Cancer

2p25.3

FAM110C

hypothetical protein LOC642273

NM_001077710

HCT116

Colon Cancer

Xq26.3

FAM122C

hypothetical protein LOC159091

NM_138819

HCT116

Colon Cancer

1p36.13

FBXO42

F-box protein 42

NM_018994

HCT116

Colon Cancer

9q31.2

FCMD

fukutin

NM_006731

HCT116

Colon Cancer

10q23.33

FER1L3

myoferlin isoform a

NM_013451

HCT116

Colon Cancer

3q28

FGF12

fibroblast growth factor 12 isoform 2

NM_004113

HCT116

Colon Cancer

4q32.3

FLJ20035

hypothetical protein LOC55601

NM_017631

HCT116

Colon Cancer

3q26.33

FXR1

fragile X mental retardation-related protein 1

NM_001013438

HCT116

Colon Cancer

9q33.3

GAPVD1

GTPase activating protein and VPS9 domains 1

NM_015635

HCT116

Colon Cancer

Xp21.3

IL1RAPL1

interleukin 1 receptor accessory protein-like 1

NM_014271

HCT116

Colon Cancer

2q36.3

IRS1

insulin receptor substrate 1

NM_005544

HCT116

Colon Cancer

10q25.1

KIAA1754

hypothetical protein LOC85450

NM_033397

HCT116

Colon Cancer

17q21.2

KRTAP4-4

keratin associated protein 4.4

NM_032524

HCT116

Colon Cancer

6q23.3

MAP7

microtubule-associated protein 7

NM_003980

HCT116

Colon Cancer

4p16.1

MIST

mast cell immunoreceptor signal transducer

NM_052964

HCT116

Colon Cancer

Xp22.2

MOSPD2

motile sperm domain containing 2

NM_152581

HCT116

Colon Cancer

16q22.1

NFAT5

nuclear factor of activated T-cells 5 isoform a

NM_006599

HCT116

Colon Cancer

18q11.2

NPC1

Niemann-Pick disease, type C1

NM_000271

HCT116

Colon Cancer

9q33.3

NR6A1

nuclear receptor subfamily 6, group A, member 1

NM_001489

HCT116

Colon Cancer

1q32.1

NUCKS1

nuclear ubiquitous casein kinase and cdk substrate 1

NM_022731

HCT116

Colon Cancer

4p15.1

PCDH7

protocadherin 7 isoform c precursor

NM_032457

HCT116

Colon Cancer

4q22.3

PDLIM5

PDZ and LIM domain 5 isoform a

NM_001011513

HCT116

Colon Cancer

15q23

PKM2

pyruvate kinase 3 isoform 1

NM_002654

HCT116

Colon Cancer

12p11.23

PPFIBP1

PTPRF interacting protein binding protein 1

NM_003622

HCT116

Colon Cancer

1p36.23

RERE

atrophin-1 like protein isoform a

NM_001042681

HCT116

Colon Cancer

1q21.3

RORC

RAR-related orphan receptor C isoform a

NM_001001523

HCT116

Colon Cancer

8q24.12

SAMD12

sterile alpha motif domain containing 12

NM_207506

HCT116

Colon Cancer

17q25.3

SEPT9

septin 9

NM_006640

HCT116

Colon Cancer

13q12.3

SLC7A1

solute carrier family 7 (cationic amino acid

NM_003045

HCT116

Colon Cancer

1p36.11

SRRM1

serine/arginine repetitive matrix 1

NM_005839

HCT116

Colon Cancer

6q25.3

SYTL3

synaptotagmin-like 3

NM_001009991

HCT116

Colon Cancer

17q23.1

TMEM49

transmembrane protein 49

NM_030938

HCT116

Colon Cancer

2q37.1

TNRC15 (GYGYF2)

trinucleotide repeat containing 15 (GRB10 interacting GYF protein 2)

NM_015575

HCT116

Colon Cancer

6p21.1

TRERF1

transcriptional regulating factor 1

NM_033502

HCT116

Colon Cancer

8q24.13

TRIB1

G-protein-coupled receptor induced protein

NM_025195

HCT116

Colon Cancer

2p23.3

UBXD4

UBX domain containing 4 (UBXN2A)

NM_181713

HCT116

Colon Cancer

10q25.2

ZDHHC6

zinc finger, DHHC domain containing 6

NM_022494

HCT116

Colon Cancer

9q33.3

ZNF79

zinc finger protein 79 (pT7)

NM_007135

A549 Lung Cancer Library

Known and Hypothetical Genes

CELL LINE

INDICATION

LOCUS

GENE NAME

GENE PRODUCT

ACCESSION NO.

A549

Lung Cancer

10p15.1

AKR1C3

aldo-keto reductase family 1, member C3

NM_003739

A549

Lung Cancer

9q21.13

ALDH1A1

aldehyde dehydrogenase 1A1

NM_000689

A549

Lung Cancer

10p11.22

C10orf68

chromosome 10 open reading frame 68

NM_024688

A549

Lung Cancer

9q22.32

C9orf3

aminopeptidase O

NM_032823

A549

Lung Cancer

10p11.22

ITGB1

integrin beta 1 isoform 1A precursor

NM_002211

A549

Lung Cancer

7p15.3

ITGB8

integrin, beta 8 precursor

NM_002214

A549

Lung Cancer

11p14.1

KIF18A

kinesin family member 18A

NM_031217

A549

Lung Cancer

5q31.3

NR3C1

nuclear receptor subfamily 3, group C, member 1

NM_001018074

A549

Lung Cancer

8p12

NRG1

neuregulin 1 isoform GGF2

NM_013962

A549

Lung Cancer

13q21.32

PCDH9

protocadherin 9 isoform 1 precursor

NM_020403

A549

Lung Cancer

7q21.3

PPP1R9A

protein phosphatase 1, regulatory (inhibitor)

NM_017650

A549

Lung Cancer

8q24.3

PTK2

PTK2 protein tyrosine kinase 2 isoform a

NM_005607

A549

Lung Cancer

3q22.1

RYK

RYK receptor-like tyrosine kinase isoform 1

NM_001005861

A549

Lung Cancer

18p11.31

TGIF

TG-interacting factor isoform a

NM_003244

A549

Lung Cancer

17q23.1

TMEM49

transmembrane protein 49

NM_030938

A549

Lung Cancer

12q23.3

TXNRD1

thioredoxin reductase 1

NM_003330

A549

Lung Cancer

7q11.23

YWHAG

tyrosine 3-monooxygenase/tryptophan

NM_012479